Author

Shou-Dong Ye

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Open access Sep 2026

Chemical Screening Identifies Danofloxacin as a Self‐Renewal Agonist of Embryonic Stem Cells through Alleviation of HDAC1‐Mediated Deacetylation of Tert and Prdm10

ABSTRACT While significant advances have been made in maintaining stem cell pluripotency, the successful establishment of embryonic stem cells (ESCs) from various animal species in vitro remains challenging. This highlights the need for further optimization of culture conditions. Through compound library screening, we...

Yan Zhang, Jun-Xiang Ji, Bao-Xing Dong et al. · Advancement of science · 0 citations

Sep 2026

Msl3-mediated H4K16ac suppresses 2C-like reprogramming by sustaining LINE1 expression in mouse embryonic stem cells.

Two-cell-like cells (2CLCs), a rare totipotent-like population within mouse embryonic stem cells (mESCs) cultures, serve as a valuable model for studying early embryonic events like zygotic genome activation. However, the molecular mechanisms restraining their spontaneous emergence remain elusive. Here, we identify Msl...

Yu-Qing Zhu, Shuo Cao, Qing-Ying Wang et al. · Stem Cells · 0 citations

Sep 2026

An Optimized Protocol for the Generation of Vascular Organoids from Human Induced Pluripotent Stem Cells.

Vascular organoids derived from human pluripotent stem cells (hPSCs) have emerged as powerful three-dimensional models for studying vascular development, disease mechanisms, and drug responses. Current vascular organoid protocols enable the generation of self-organizing endothelial-pericyte networks; however, batch-to-...

Qiang Song, Yu-Qing Zhu, Shou-Dong Ye · Journal of Visualized Experi... · 0 citations