Author

Shou-Rong Wu

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Review Sep 2026

Transcriptional and epigenetic regulation of ferroptosis in cancer drug resistance: Mechanisms and targeted therapeutic opportunities.

It is proposed that transcriptional-epigenetic crosstalk represents the core driver of ferroptosis plasticity, enabling cancer cells to dynamically adapt to therapeutic stress, and bridges mechanistic epigenetic biology with translational pharmacology, providing a valuable reference for overcoming cancer drug resistanc...

Ze-Nan Xu, Man-Xuan Zhang, Muhammad Faseeh et al. · Biochemical Pharmacology · 0 citations

Open access Sep 2026

YAP-mediated mechanotransduction promotes hepatocellular carcinoma progression by targeting ATP1A1/CXCL1 axis.

It is demonstrated that increased matrix stiffness activates YAP/TEAD4-dependent transcriptional program and promotes ATP1A1 expression, thereby converting mechanical cues into chemical signaling output and finally promoting malignant phenotypes in the tumor.

Meng-Nan Zhang, Xin-Peng Wen, Jingyi Liu et al. · Acta Pharmacologica Sinica · 0 citations