Intranasal Delivery of Piceatannol-Loaded Liposomes for Glioblastoma Management: Formulation Optimization, In Vitro, Ex Vivo, In Ovo and LC-MS/MS- Based In Vivo Pharmacokinetic and Brain Distribution Assessment
Overall, this research establishes PIC-LPO as a safe, non-invasive, and effective strategy to enhance brain delivery and antiangiogenic therapy, highlighting the translational potential of PIC for GBM management.