Author

Shreeya Garg

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Open access Sep 2026

Multiple local PfDHFR I164L haplotype expansions drive Plasmodium falciparum antifolate resistance in Uganda

Mutations in the Plasmodium falciparum genes, pfdhfr and pfdhps, drive antifolate resistance and threaten malaria control in regions where sulfadoxine-pyrimethamine (SP) is the primary chemoprevention strategy. The spatial patterns and evolutionary dynamics of these mutations in high-transmission settings remain incomp...

V. Asua, K. Niaré, Shreeya Garg et al. · Nature Communications · 1 citation

Structure − Activity Relationship Study of Antimalarial Asparagine-Derived Proteasome Inhibitors

Cryo-EM structural studies reveal a novel binding pose of the inhibitor at the Pf 20S β 5 active site, explaining the enhanced activity of an N -cap sulfonamide modification compared to an N -cap amide, and offer insights into the development of next-generation antimalarial Pf 20S-targeting compounds with improved drug...

Hao Zhang, Da-Qiang Li, Hao-Chi Hsu et al. · 0 citations