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Author

Shreyasi Majumdar

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Sep 2026

Dendrimer Delivered shRNA Targeting the CCL20–CCR6 Axis Suppresses Complement-Mediated Microglial Synaptic Pruning and Ameliorates Chronic Neuroinflammation After Repetitive Traumatic Brain Injury

Repetitive traumatic brain injury (rTBI) induces persistent microglial activation and chronic neuroinflammation, yet the upstream signals driving long⍰term synaptic injury remain unclear. In this study, we identify the CCL20–CCR6 chemokine axis as a critical regulator of sustained microglial activation and complement⍰d...

K. Mayilsamy, P. Patel, Ryan Green et al. · 0 citations
Review Open access Sep 2026

Microbiota-mitochondria axis in neurodegenerative disorders and retinal dysfunction: mechanisms and emerging therapeutic opportunities

Current evidence represents the microbiota–mitochondria axis as a one of the promising mechanistic and therapeutic targets for neurodegenerative and ocular diseases, however, most therapeutic evidence discussed in this review is derived from preclinical studies, with relatively limited clinical validation.

Puneet K. Samaiya, Akshat Agrawal, Shrija Kesharwani et al. · 0 citations

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