Open access
Jul 2026
The E3 Ubiquitin Ligase RLIM Safeguards Oligodendrocyte Development and Myelination by Targeting SLC7A11 for Polyubiquitination to Regulate Ferroptotic Resistance
The findings reveal that the RLIM–SLC7A11‐GSH signaling axis governs ferroptosis resistance in OL lineage cells, implicates this pathway in RLIM‐related neurodevelopmental disorders, and suggests GSH as a potential therapeutic strategy.
Yu-Wei Li, Hai-Jun Zhang, Jie-Ya Zhou et al.
· Advancement of science · 0 citations