Phenylacetylglutamine restrains epithelial ferroptosis in intestinal ischemia-reperfusion by coupling lipid droplet-mitochondria remodeling to metabolic execution.
BACKGROUND Intestinal ischemia-reperfusion injury (IIR) involves epithelial barrier failure, oxidative stress, and ferroptosis-associated lipid damage, yet how lipid droplet-mitochondria coupling influences ferroptotic susceptibility remains incompletely understood. METHODS Untargeted plasma metabolomics was combined...