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Author

Shu-Lei Zhu

2 papers indexed here

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Sep 2026

FAPi-Mediated siRNA Lipid Nanoparticles for the Treatment of Liver Fibrosis.

Liver fibrosis lacks effective therapies largely due to the inability of conventional lipid nanoparticles (LNPs) to target activated hepatic stellate cells (HSCs), the primary drivers of fibrotic progression. Here, we developed a fibroblast activation protein inhibitor (FAPi)-modified LNP encapsulating heat shock prote...

Ru-Lan Feng, Shu-Lei Zhu, Zi-Jun Yao et al. · 0 citations
Jul 2026

Spatially Driven DNA-Based Probe Proximity Assay for Total Antibody Quantification in Antibody-Drug Conjugates.

This method reduces the recovery loss caused by decreased affinity from payload conjugation and delivers comparable signals for trastuzumab, T-DM1, and T-DXd, which provides a novel approach to address accuracy issues arising from affinity changes due to ADC dynamics in vivo.

Zhiwei Chen, Yu-Ling Liao, Ying Zhou et al. · 0 citations

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