Open access
Aug 2026
Immune niche composed of C1Q+ macrophages/SFRP2+ CAFs/CD8+ T cells drives immunotherapy response in HER2-positive gastric cancer
Human epidermal growth factor receptor 2 (HER2) expression is a distinctive feature of a subgroup of gastric cancer (GC) but the underpinning characteristics of the immune microenvironment and mechanisms remain unclear. In the study, spatial transcriptomics and single-cell RNA sequencing are used on treatment-naïve HER...
Yu-Han Liao, Xin-Hua Chen, Hai-Yun Chen et al.
· Nature Communications · 0 citations