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Shu-Wen Wu

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Sep 2026

Identification of Novel Acylthiourea-Based PROTACs Exhibiting Broad-Spectrum Antiviral Activity against Enteroviruses

Enteroviruses are the primary cause of hand, foot, and mouth disease (HFMD). The absence of broad-spectrum antivirals, due to high serotypic and genetic diversity, greatly hampers effective treatment. In this study, we developed a novel type of acylthiourea-based proteolysis-targeting chimeras (PROTACs) to induce tar...

Yu-Meng Cai, Mao-Ze Yang, Lei Yu et al. · 0 citations
Open access Sep 2026

Exploring novel isatin derivatives as SARS-CoV-2 3CLpro inhibitors

A series of novel isatin derivatives synthesised by incorporating phenyl, biphenyl, naphthyl and indolyl moieties into the N-1 position and screened in vitro against SARS-CoV-2 3CLpro were strong inhibitors of SARS-CoV-2 3CLpro.

Jian Song, Cai Shi, Bo-Ning Yang et al. · 0 citations

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