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Author

Shu-Wen Xue

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Oct 2026

Discovery of C5-Substituted 2′-Fluorinated Pyrimidine Nucleosides as Potent and Orally Efficacious Anti-HSV Agents

Herpes simplex virus (HSV) infections remain a significant global health concern. Through phenotypic screening of a nucleoside-focused library followed by systematic structure−activity relationship (SAR) explorations, we identified C5-substituted 2′-fluorinated pyrimidine nucleosides as promising anti-HSV scaffolds....

Ye Li, Wen-Bo Zhang, Shu-Wen Xue et al. · 0 citations

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