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Author

Shuya Li

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Review Sep 2026

Lysine specific demethylase 5B promises to be a new focus of cancer drug-resistance: combination therapy.

Drug resistance remains a major obstacle to the long-term efficacy of cancer therapy. Lysine specific demethylase 5B (KDM5B), an epigenetic regulator of H3K4 methylation, has emerged as an important modulator of therapeutic resistance across multiple tumor contexts. In this review, we systematically summarize the mecha...

Ya-Quan Cao, Shu-Ya Li, Tian-Gui Wu et al. · 0 citations
Aug 2026

Phenotypic discovery of a pyrimidine derivative with dual anti-prostate cancer and cardioprotective potential via ROS modulation.

Results identify 9v as a promising lead compound with both anti-prostate cancer activity and cardioprotective potential in an in vitro oxidative stress model, providing a basis for the development of multifunctional anticancer agents with improved cardiovascular safety.

Yaquan Cao, Ya-Xi Wu, Yunfei Li et al. · 0 citations

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