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Shuyan Li

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Open access Sep 2026

Multilevel synergistic anticancer mechanisms of Punica granatum L. peel polyphenols targeting the pan-cancer proliferation target PCNA: a combined analysis based on network pharmacology, molecular dynamics simulation, and UPLC-Q-TOF-HRMS

Punica granatum L. peel is rich in tannins and flavonoids. Modern pharmacological studies have indicated its multi-target anticancer potential; however, the molecular recognition mechanisms between its active components and key targets remain to be systematically clarified. In this study, network pharmacology, com...

Shi-Jia Lu, Meng-Jia Yan, H. Du et al. · 0 citations
Open access Aug 2026

Insomnia Increases Susceptibility to Sciatica: Evidence from Mendelian Randomization and Integrative Genetic Analyses

Background Neuropathic pain (NP) frequently co-occurs with sleep disorders, yet the causal relationship between the two remain unclear, necessitating further investigation to elucidate their intrinsic connection. Methods We conducted linkage disequilibrium score regression (LDSC), Mendelian randomization (MR), multivar...

Shuyan Li, Xianmei Chen, Hai-Wen Cen et al. · 0 citations

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