Author

Shuai Chen

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Review Open access Sep 2026

Hyperbaric oxygen therapy in sepsis-associated encephalopathy: pathophysiological rationale, preclinical evidence, and translational challenges

Sepsis-associated encephalopathy (SAE) is a serious neurological complication of sepsis that can cause acute cerebral dysfunction and long-term cognitive impairment. Its pathogenesis involves multiple pathological processes, including blood–brain barrier (BBB) disruption, neuroinflammation, microglial and astrocytic re...

Yi-Kun Xie, Yi-Hao Li, Yu-Jing Li et al. · Frontiers in Cellular Neuros... · 0 citations

Sep 2026

Stepwise neutrophil-to-neuron targeting nanotherapy for mitochondrial protection and blood-brain barrier preservation in ischemic stroke.

A dual-modal, stepwise-targeting lipid nanoparticle platform that integrates mitochondrial protection with matrix metalloproteinase-12 (MMP-12) silencing to achieve coordinated neurovascular protection in ischemic stroke is reported.

Xu-Rui Gu, Sai Wang, Lei Chen et al. · Journal of Controlled Releas... · 0 citations