Shuai-Jie Zhu

Ferrostatin-1-loaded polymeric micelles with IMTP modification and ROS responsiveness alleviate post-resuscitation myocardial dysfunction by inhibiting ferroptosis.

Post-resuscitation myocardial dysfunction (PRMD) is a leading cause of early mortality following cardiac arrest (CA), and ferroptosis has been implicated as a key mechanism. However, effective ferroptosis-targeted therapies are limited. Here, we developed ischemic myocardium-targeting peptide (IMTP)-modified, reactive...