Open access
Sep 2026
Novel quinoline-2-one derivatives as potent receptor Interacting protein kinase 1 (RIPK1) inhibitors with therapeutic activities for acute respiratory distress syndrome
As a key regulator of cellular programmed necrosis and inflammatory signaling pathways, receptor interacting protein kinase 1 (RIPK1) is closely linked to the pathogenesis and progression of acute respiratory distress syndrome (ARDS). In this study, building on hits identified from docking simulations, a series of qu...
Wei-Gang He, Long-Yang Zhao, Ya-Dong Liu et al.
· Arabian Journal of Chemistry · 0 citations