Antibody-dependent enhancement (ADE) remains a major hurdle for flavivirus vaccine development. Engineering the fusion loop (FL) represents a promising solution, yet validations restricted to murine models limit human translatability due to profound species divergence. Here, we provide a primate-level demonstration tha...
Chen-Xi Yang, Shu-Xin Guo, Ya-Ming Lu et al.· Cell Reports Medicine· 0 citations
A diarylamide molecule, compound 10 (compd. 10), is reported, which inhibits SARS-CoV-2 more potently than the parent clofoctol, and provides a chemotype for host-directed antiviral development.
Xintian Zhang, Tingfu Du, Yong-Jian Wang et al.· iScience· 0 citations
The successfully developed novel 6-9ΔGΔ51+S226R-H5N1 vaccine candidate not only exhibits excellent safety and immunogenicity but also represents a powerful potential tool for the effective prevention and control of highly pathogenic avian influenza.
Ziteng Liang, Meng-Yi Zhang, Jie Zhang et al.· Signal Transduction and Targ...· 0 citations
BACKGROUND
The global emergence of monkeypox virus (MPXV) highlights the urgent need for a deeper understanding of host-pathogen interactions. Although transcriptional responses to MPXV infection have been characterized, the role of epitranscriptomic regulation particularly N6‑methyladenosine (m6A) modification remains...
R. Tang, Jin-Di Huang, Wenhai Yu et al.· Cell communication and signa...· 0 citations
The design and preclinical evaluation of SV suggest that heterodimeric RBD architectures incorporating antigenically divergent variants may represent a generalizable platform for countering viral immune evasion, with implications for future SARS-CoV-2 variants and other rapidly evolving viral pathogens.
