Author

Shuang Cao

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Open access Sep 2026

DiffGSP: reversing mRNA diffusion to unlock high-fidelity spatial transcriptomics

Spatial transcriptomics enables gene expression profiling within intact tissues while preserving spatial context, providing unprecedented insights into cellular organization and function. However, mRNA diffusion during tissue processing can cause transcripts originating from adjacent cells to be captured at a given spo...

Ji-Xin Liu, Shu-Li Sun, Yang Xu et al. · bioRxiv · 0 citations

Open access Aug 2026

A versatile phenotyping platform combining three-photon microscopy, optimized tissue clearing, and deep-learning signal separation for full-depth multi-organelle phenotyping.

Imaging the internal structure of plant organs at the subcellular level is essential for understanding key processes such as photosynthesis, growth, and stress responses. Yet conventional optical microscopy struggles to visualize deep tissues due to intense light scattering and spectral crosstalk from autofluorescent c...

Mubin He, Yi-Ru Xu, Meiji Zhu et al. · Plant Communications · 0 citations