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Author

Shuang Qiu

2 papers indexed here

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Aug 2026

Bifunctional Ionophores for Cuproptosis Activation: Dual Targeting of Copper and Fe-S Protein Homeostasis.

Cellular resilience to therapy often arises from adaptive mechanisms that safeguard iron-sulfur (Fe-S) proteins. Here, we present a rational strategy to overcome such resilience by integrating two synergistic vulnerabilities, copper toxicity and Fe-S cluster homeostasis, into a single molecular scaffold. Inspired by a...

Liuxin Yang, Yiyu Cheng, Si Qin et al. · 0 citations
Aug 2026

Lipoic acid-conjugated chalcones exert antitumor activity via ROS elevation and ferroptosis.

Overcoming drug resistance and minimizing off-target toxicity remain major challenges in cancer therapy. Ferroptosis, an iron-dependent form of regulated cell death driven by lipid peroxidation, has emerged as a promising therapeutic target. Natural chalcones exhibit antitumor properties linked to oxidative stress indu...

Xin-Yue Bi, Haifu Sun, Kaihong Wang et al. · 0 citations

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