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Shuang-Yu Li

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Open access Sep 2026

Bruceine A attenuates renal tubulointerstitial fibrosis by inhibiting the Wnt7a/PI3K/AKT pathway

Introduction Tubulointerstitial fibrosis (TIF) is a major pathological feature of progressive chronic kidney disease (CKD), yet effective pharmacological therapies remain limited. Bruceine A (BA), a quassinoid isolated from Brucea javanica, has been reported to exert renoprotective effects in glomerular diseases. Howev...

Shuang-Yu Li, Ren-Qing Wang, Tong Wang et al. · 0 citations
Open access Sep 2026

Combined Taraxacum mongolicum and Astragalus polysaccharides attenuate CCl4-induced hepatic fibrosis through modulation of the TLR4/MyD88/NF-κB signaling pathway and gut microbiota composition

TMP combined with APS exerts enhanced anti-hepatic fibrosis effects compared with either monotherapy, and is associated with changes in gut microbiota composition, elevated fecal short-chain fatty acid levels, and reduced expression of hepatic TLR4/MyD88/NF-κB pathway-related molecules.

Yin-Jie Ma, Chao-Xing Wang, Xue Chen et al. · 0 citations

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