Exercise is associated with favorable brain and cognitive outcomes, yet the supporting evidence spans molecular, cellular, organ, neural-circuit, imaging, and behavioral levels that differ substantially in causal strength. This narrative review develops an integrative framework across biological levels in which exerc...
Dong-Jing Yin, Cheng Luo, Juan-Juan Hu et al.· Frontiers in Integrative Neu...· 0 citations
This review examines how nicotinamide (NAM) metabolism may contribute to malignant remodeling of the TME at three interconnected levels: fueling the hypermetabolic state of cancer cells and contributing to TME acidification; modulating tumor angiogenesis; and establishing and sustaining an immunosuppressive, chronic in...
Wei-Dong Sun, Shuang-Zhou Bi, Xiao-Juan Zhu et al.· Critical reviews in oncology...· 0 citations
The multifaceted pro-tumorigenic mechanisms through which nicotinamide phosphoribosyltransferase (NAMPT) regulates key features of the TME, including macrophage polarization and immune responses, metabolic reprogramming and TME acidification, angiogenesis, and the maintenance of epithelial-mesenchymal transition and ca...
