Phytochemical Modulation of the p53 Tumor Suppressor Pathway: Mechanistic Insights, Translational Evidence, and Therapeutic Perspectives in Cancer
Cancer is a major global health challenge, with p53 mutations occurring in over 50% of human cancers and contributing to impaired DNA repair and apoptosis. In more recent work, phytochemicals in herbs such as curcumin, resveratrol, genistein, berberine, and withaferin A were found to enhance p53 activity or rescue...