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Shuhei Kuwabara

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Open access Jul 2026

Notch signaling pathway mediates anti-inflammatory effects of vagus nerve stimulation during lipopolysaccharide-induced acute kidney injury.

Using a mouse model of lipopolysaccharide (LPS)-induced AKI, it is found that CAP activation by vagus nerve stimulation (VNS) enhanced Notch2 signaling in macrophages, mitigating inflammation in the spleen and tissue damage in the kidneys, thereby protecting the kidneys.

Shuhei Kuwabara, Hiro Inoue, W. Nash et al. · 0 citations