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Open access Aug 2026

Glutathione S‐Transferase Omega 1 Promotes Macrophage Inflammation‐Associated Coagulopathy in Sepsis by S‐Glutathionylating ANXA5 to Enhance Its Ubiquitination

Sepsis‐associated coagulopathy contributes to organ dysfunction and mortality. Macrophage‐mediated inflammation disrupts anticoagulant homeostasis, but the role of glutathione S‐transferase omega 1 (GSTO1) in this process remains unclear. Clinical samples from sepsis patients were analyzed for correlations among GSTO1,...

Jia-Pei Peng, Chang-Mei Hu, Xiao-Hua Fu et al. · 0 citations
Jul 2026

Genomic Disruption of CAMKMT by t(2;11)(p21;q23) Reveals a Glycolytic Reprogramming Mechanism in Acute Myeloid Leukemia.

INTRODUCTION The t(2;11)(p21;q23) translocation without KMT2A rearrangement has been reported in ~16 hematologic neoplasms, but its molecular target(s) remain unknown. We aimed to identify the genes disrupted by this translocation and to clarify its contribution to Acute Myeloid Leukemia (AML) pathogenesis. METHODS W...

Shujun Li, Xiaoshan Yang, Peng Fang et al. · 0 citations

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