Shun-Tian Zhu

YAP/TAZ in vascular homeostasis and disease: context-dependent regulation and therapeutic opportunities

Vascular homeostasis depends on coordinated responses among endothelial cells, vascular smooth muscle cells, and perivascular cells. The Hippo pathway effectors Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) integrate mechanical, metabolic, and biochemical cues within these ce...