Shun Zhang

Multivariate GWAS framework for family trios with parental phenotypes to control dynastic effects

Effect size estimates in genome-wide association studies (GWAS) and Mendelian randomization (MR) based on unrelated individuals are often confounded by dynastic effects (DE). Existing family-trio-based methods can mitigate this bias, but they typically discard parental phenotypes and cannot jointly model multiple corre...