Author

Shuo-Bin Chen

2 papers indexed here

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Aug 2026

Lead Optimization of Quinoline-Coumarin KRAS mRNA G-Quadruplex Ligands: Discovery of Non-Quaternary Ammonium Analogs as Translation Inhibitors.

This study designed and synthesized a series of nonquaternary ammonium analogs to investigate whether this structural motif could be removed without compromising KRAS rG4-related activity and identified Q29 as a promising lead for further development of KRAS translation inhibitors.

Mao-Lin Li, Wen-Wei Li, Wen-Li Fu et al. · Journal of Medicinal Chemist... · 0 citations

Aug 2026

Discovery and Biosynthesis of Brasilanes G−L: N -Acetylglucosamine-Decorated Sesquiterpenoids with Anti-Inflammatory Activity

N-Acetylglucosamine (GlcNAc)-decorated natural products represent a structurally unique class of metabolites that possess diverse biological activities. Through the genome mining of Coccidioides sp. CMB-TN39F, we identified a GlcNAc transferase-encoding terpene synthase gene cluster brc. Heterologous expression of th...

Ming-Min Wu, Yao-Hui Shi, Yu-Wei Lin et al. · Journal of Natural Products · 0 citations