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Author

Shuo-Lin Weng

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Open access Sep 2026

Molecular origins of pH gradients in charge-regulated biomolecular condensates.

The buffered Charge-Regulation Monte Carlo (b-CR-MC) framework is introduced, which couples grand-canonical exchange of ions and buffer species with explicit charge regulation of titratable residues and enables quantitative prediction of how mutations and post-translational modifications reprogram condensate microenvir...

Shuo-Lin Weng, Shiv Rekhi, Young C. Kim et al. · 0 citations
Open access Aug 2026

Condensate Material Properties Influence Cargo Selection for Neuronal Extrusion via Large Extracellular Exopher Vesicles

Findings reveal that gel-like condensates with slower dynamics and higher viscoelasticity localize to exophers more avidly than dynamic liquid-like condensates, demonstrating a strong correlation between condensate dynamics and exopher recruitment.

Mayur Barai, E. Chuang, Shuo-Lin Weng et al. · 0 citations
Open access Jul 2026

Molecular Origins of pH Gradients in Charge-Regulated Biomolecular Condensates

Biomolecular condensates exhibit spontaneous electrochemical microenvironments characterized by asymmetric ion distributions and pH gradients that emerge from protein-sequence-dependent charge regulation. Despite their biological importance, mechanistic understanding of these microenvironments has been constrained by t...

Shuo-Lin Weng, Shiv Rekhi, Young C. Kim et al. · 0 citations

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