Integrated Single-Nucleus and Epigenomic Profiling Reveals Coordinated Neuro-Glial and Chromatin Remodeling in the Type 2 Diabetic Hypothalamus
Highlights What are the main findings? • Integrated single-nucleus transcriptomic and tissue-level chromatin accessibility profiling identifies coordinated neuronal, oligodendrocyte-lineage, and regulatory remodeling in the hypothalamus of an HFD/STZ-induced T2D mouse model.• Multi-omic evidence highlights activation o...