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Author

Shweta Modgil

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Open access Sep 2026

Targeting prostaglandin catabolism via topical nanotherapy rescues vision in ischemic optic neuropathy

These findings establish 15-PGDH–mediated prostaglandin catabolism as a therapeutic target in ischemic optic neuropathy and demonstrate a clinically translatable nanotherapeutic strategy for protecting the central nervous system from ischemic neurodegeneration.

Shweta Modgil, Rusiou Hsu, M. Shariati et al. · 0 citations
Open access Aug 2026

RGC-specific reversal of lipid peroxidation drives neuroprotection and vision restoration in optic nerve ischemia by targeting GPX4

Lipid peroxidation is established as mechanism of vision loss in NAION, and targeting GPX4 leads to neuroprotection and visual restoration and identifies GPX4 as a key molecular determinant of retinal ganglion cell resilience.

Ming Yang, Jie Pan, Shweta Modgil et al. · 0 citations

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