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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Si-Chao Tian

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Open access Sep 2026

Targeting CTGF+ cancer-associated fibroblasts disrupts tumor-stroma crosstalk in pancreatic ductal adenocarcinoma.

Targeting CTGF+ CAFs with QX03-46 significantly disrupted the CTGF/TGF-β1 signaling axis and suppressed CAF functions, resulting in decreased extracellular matrix deposition and oncogenic cytokine secretion and position QX03-46 as a promising therapeutic candidate for targeting the fibrotic TME.

Yi-Wen Shen, Qing-Yan Sun, Yunzhe Wang et al. · 0 citations

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