Si-Chuang Tan

HSF1 Protects Against Sepsis by Transcriptionally Upregulating Neutrophil C5aR1 to Enhance Antimicrobial Defense.

Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. The resulting septic shock and multiple organ dysfunction syndrome (MODS) are the primary drivers of mortality. Heat shock factor 1 (HSF1), a master transcription factor regulating cellular stress responses, has been sho...