Ultrafast 4-Azidopyridinium-Based Staudinger (UApS) Ligation for Bioorthogonal Labeling and Imaging.
Fast click reactions that operate efficiently in aqueous buffers are highly desirable across many areas of chemistry, yet remain scarce. Herein, we report an ultrafast 4-azidopyridinium-based Staudinger (UApS) ligation that proceeds with large bimolecular reaction rate constants (103-104 M-1s-1) under catalyst-free, ph...