Author

Simai Wang

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Open access Oct 2026

SETDB1 preferentially silences evolutionarily young retroelements.

Long-read RNA sequencing mapped to a telomere-to-telomere mouse genome assembly is used to resolve the specific contributions of SETDB1 to TE silencing at single-locus resolution and provide a framework for dissecting how chromatin-based mechanisms cooperate to maintain subclass-selective TE repression.

Bercin K. Cenik, Si-Mai Wang, Marta Iwanaszko et al. · Proceedings of the National... · 0 citations

Open access Aug 2026

Maintenance of nucleosome organization through replication and transcription counteracts aberrant coalescence of active chromatin.

Nucleosomes with their associated modifications organize and regulate the genome. It is unclear how this is integrated with the requirement of replication and transcription to access the DNA template without jeopardizing chromatin function. Here, we reveal a unified requirement for the histone chaperone FACT in mediati...

R. C. M. Frater, Rikke Rejnholdt Jensen, Joaquim Ollé López et al. · Molecules and Cells · 0 citations