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Si-Man Guo

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Open access Oct 2026

Neuronal progranulin in the medial prefrontal cortex mediates stress-induced despair-like behaviors and impaired neuroplasticity.

BACKGROUND Neuroplasticity in the medial prefrontal cortex (mPFC) is critically implicated in major depressive disorder (MDD). Progranulin (PGRN), a multifunctional protein that is abundant in the cortex, regulates neuronal development and synaptic maintenance, positioning it as a candidate therapeutic target for MDD....

Yun-Feng Wang, Yao Yang, Si-Man Guo et al. · 0 citations

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