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Author

Si-Mei Zhou

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3 papers indexed here

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Sep 2026

Discovery and Structural Basis of Zoledronic Acid as a Potent SPS-Targeting Herbicide.

Solanesyl diphosphate synthase (SPS) is essential for plastoquinone-9 (PQ-9) biosynthesis and has emerged as a promising target for herbicide discovery. The commercial SPS herbicides bind to the dimer interface of the protein; however, substrate-competitive SPS inhibitors are still rare, particularly in agronomically r...

Min Li, Si-Mei Zhou, Jian-Guo Wei et al. · 0 citations
Sep 2026

Structural Basis of Solanesyl Diphosphate Synthase Inhibition by Rimisoxafen

Solanesyl diphosphate synthase (SPS; EC 2.5.1.85), a key enzyme in plastoquinone biosynthesis, has emerged as a promising herbicide target. Rimisoxafen is a bleaching herbicide that inhibits both SPS and phytoene desaturase (PDS), but the mechanism underlying SPS inhibition remains unclear. Here, we show that rimisox...

Han Xiao, Min Li, Jian-Guo Wei et al. · 0 citations
Jul 2026

Shielding Metabolic Hotspots in the Triketone-Quinoline Scaffold Yields Potent 4-Hydroxyphenylpyruvate Dioxygenase Inhibitors.

4-Hydroxyphenylpyruvate dioxygenase (HPPD; EC 1.13.11.27) is an important target for modern herbicide discovery. To translate HPPD inhibitors into effective herbicide candidates, we developed a metabolism-oriented design strategy to improve the in vivo efficacy of triketone-quinoline HPPD inhibitors. By shielding the m...

Min Li, Han Xiao, Si-Mei Zhou et al. · 0 citations

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