Sep 2026
Antibacterial Cyclic Oligo(disulfide)s with Tunable Hydrophilicity Dictate Membrane Interactions and Distinct Metabolic Interference
Using naturally occurring lipoic acid, cationic cyclic oligo(disulfide)s (CCOs) are designed that induce targeted membrane depolarization and trigger distinct downstream metabolic responses that represent a tunable antimicrobial system with considerable clinical translation potential.
Jia Guo, Si-Qi Zhang, Guang-Yuan Xu et al.
· Biomacromolecules · 0 citations