Causal interplay between major depressive disorder and cognitive impairment: A bidirectional Mendelian randomization study with brain imaging mediation.
BACKGROUND Major depressive disorder (MDD) features widespread cognitive impairments, some pre-existing before onset. However, the causal associations between MDD and multidimensional cognitive impairments, and the structural and functional neural underpinnings mediating these relationships, remain to be elucidated....