Author

Si-Si Tan

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Open access Sep 2026

Ketogenic diet attenuates Müller cell activation and retinal neuroinflammation in autoimmune glaucoma through acetylation-mediated FOXO signalling

Glaucoma consists of a group of neurodegenerative diseases characterized by retinal ganglion cell degeneration, in which Müller cells are increasingly recognised as drivers of neuroinflammation. A ketogenic diet (KD) elevates circulating β-hydroxybutyrate (BHB) and exhibits benefits in other neurodegenerative disorders...

Si-Si Tan, Xiao-Chen Wang, Yun-Fan Zheng et al. · International Journal of Mol... · 0 citations

Open access Sep 2026

Chitosan-selenium nanoparticles prevent retinal ganglion cell apoptosis in glaucoma via activation of the PI3K/Akt/Nrf2 antioxidant axis.

Glaucoma is a prominent global cause of irreversible vision loss, fundamentally driven by the continuous degeneration and ultimate death of retinal ganglion cells (RGCs), in which persistent oxidative stress plays a pivotal role. While selenium (Se) offers robust endogenous antioxidant defense, the severe toxicity and...

Yu-Jia Huo, Miao Wei, Xiao Fan et al. · Biochemical Pharmacology · 0 citations

Sep 2026

Andrographolide-loaded PLGA nanoparticles protect retinal ganglion cells against experimental acute glaucomatous injury and attenuate mitochondrial dysfunction and retinal PANoptosis-related changes.

Developed ADR-loaded poly(lactic-co-glycolic acid) nanoparticles (ADR-NPs) and evaluated their protective effects in oxygen-glucose deprivation/recovery (OGD/R)-injured R28 cells and a rat retinal ischemia/reperfusion (RIR) model protected against experimental acute glaucomatous injury by attenuating oxidative stress,...

Xiao Fan, Ruo-Tong Ouyang, Yu-Jia Huo et al. · International journal of pha... · 0 citations