Si-Si Xu

Lipotoxicity-induced ER-mitochondrial hypercoupling activates the mtDNA-cGAS-STING-NF-κB axis to drive follicular arrest in metabolically compromised PCOS

Melatonin emerged as a superior therapeutic candidate, preserving organelle architecture, preventing calcium dysregulation, blocking mtDNA release, and attenuating inflammation both in vitro and in a PCOS mouse model, and position melatonin as a clinically translatable therapeutic agent for rescuing follicular developm...