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Author

Si-Sim Kang

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Open access Oct 2026

HIF-1–mediated PPME1 expression promotes breast cancer progression via AKT activation and β-catenin recruitment

Hypoxia-inducible factor 1 (HIF-1) orchestrates the transcriptional regulation of thousands of genes involved in breast cancer (BC) progression. Here, we identified protein phosphatase 2A (PP2A) methylesterase 1 (PPME1) as a critical HIF-1 target gene that drives oncogenic signaling under hypoxic conditions. In BC cell...

Yajing Lyu, Varen Talwar, Yong-Kang Yang et al. · 0 citations
Jul 2026

Nanoscale artificial antigen presenting cells to expand human antigen-specific cytotoxic CD4 T cells for immunotherapy 2258982

The data show that nanoscale aAPCs reliably expand functional antigen-specific CD4 T cells from human PBMCs, providing both mechanistic insight into cytotoxic CD4 biology and a translational foundation for antigen-specific cell immunotherapy.

Si-Sim Kang, Mu-Qing Zhang, Shuyi Li et al. · 0 citations

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