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Si-Yao Yu

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Open access Sep 2026

The active ingredient madecassoside in Huyan no. 1 formula ameliorates D-gal-induced renal aging through the AMPK/MAPK/AP-1 signaling pathway.

BACKGROUND Renal aging accelerates overall organismal aging. The traditional Chinese medicine formula Huyan I (HY-1) has been shown to slow the decline in kidney function, but its pharmacological mechanism is unclear. This study focuses on its active component, madecassoside (MA), aiming to elucidate how it delays rena...

Li-Yan Huang, Si-Yao Yu, Yi-Ning He et al. · 0 citations

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