Author

Si-Yue Chen

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Review Open access Aug 2026

Lactylation at the crossroads of metabolism and immunity in renal injury and transplant rejection.

Understanding the role of lactylation and lactic acid-induced immune cell malfunction in renal pathophysiology provides not only mechanistic insight but also potential therapeutic targets for acute kidney injury, chronic kidney disease, and transplant rejection.

Boyang Yu, Yufeng Zhao, Jiaheng Wu et al. · International Immunopharmaco... · 0 citations

Review Sep 2026

A Unified Mechanistic Framework for Copper Toxicity in Neutrophils: Metabolic Rewiring, Cell-Death Crosstalk, and Immune Dysfunction.

By tracing individual routes from copper-pool disruption to defined cellular and tissue-level outcomes, this model distinguishes systemic copper overload from inflammatory copper redistribution and identifies the measurements required to establish copper-dependent neutrophil pathology in human disease.

Rui-Rui Shi, Si-Yue Chen, Ting-Ting Chen et al. · Antioxidants and Redox Signa... · 0 citations