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Author

Siavash Moghadami

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Open access Sep 2026

Lamin-ating the genome: quantitative gatekeeping of replication initiation

Discovered in the 1970s, nuclear lamins control chromatin organization and are linked to many diseases. Zhang et al. now find that lamin A/C quantitatively constrains DNA replication initiation by limiting chromatin accessibility and sequestering PCNA, extending lamin’s long-known role in replication to the control of...

B. Parasar, Siavash Moghadami, Long-Zhi Tan · 0 citations

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