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Siddhesh S. Kamat

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Open access Sep 2026

Orthogonal Chemical Proteomic Strategies Reveal the Cholesteryl Ester Interactome in Mammalian Cells

Cholesteryl esters (CEs) are widely regarded as inert storage forms of cholesterol, yet their potential to directly engage cellular proteins remains largely unexplored. Here, we establish an integrated chemical proteomic platform to systematically define CE–protein interactions in mammalian cells. We developed and comp...

Aakash Chandramouli, Kavita Sharma, Adithya Kallattu et al. · 0 citations
Open access Jul 2026

A lipid acyl code-based Dip2-Pkc1 signalling axis maintains mitochondrial integrity in eukaryotes

This study uncovers a novel, Dip2-mediated, unconventional Pkc1 signalling axis for maintaining mitochondrial homeostasis under nutrient transition and highlights how distinct lipid fingerprints enable precise control over organellar homeostasis.

Santhosh Kumar, Sakshi Shambhavi, Azeen Zehra et al. · 0 citations

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