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Sponsored AI Networking Cookbook: Practical recipes for AI-assisted network automation and development AI Networking Cookbook: Practical recipes for AI-assisted network automation and development

Author

Sila K. Ultanir

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Open access Sep 2026

Microtubule-associated protein 1S phosphorylation regulates dynein-driven transport in the brain and synaptogenesis in neurons.

Cyclin-dependent kinase like 5 (CDKL5) is a serine-threonine kinase enriched in the mammalian brain whose loss of function causes a severe developmental and epileptic encephalopathy named CDKL5 Deficiency Disorder. We previously showed that CDKL5 phosphorylates the microtubule-associated protein MAP1S, but how this reg...

A. T. Lopes, Ondine Janiv, Suzanne Claxton et al. · 0 citations
Open access Jul 2026

The LRRK2 G2019S variant rewires Rab GTPase phosphorylation after lysosomal damage and promotes cell death in human macrophages

It is shown that LRRK2 G2019S has an effect during lysosomal damage through kinase-dependent and kinase-independent mechanisms, and isogenic induced pluripotent stem cells from patients carrying the LRRK2 G2019S variant confirmed that LRRK2 G2019S macrophages are more susceptible to cell death in a kinase-independent m...

Rebecca Morrison, Simeon R. Mihaylov, Chak-Hon Luk et al. · 1 citation

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