Silvan Spiri

A role for selective ER autophagy in gametogenic rejuvenation revealed by high-throughput lifespan profiling

During mitotic growth, Saccharomyces cerevisiae cells age by dividing asymmetrically, producing young daughter cells while retaining age-associated damage in the mother cell, which will eventually become senescent. Gametogenesis naturally and fully resets precursor cell lifespan, even for replicatively aged cells...