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Author

Silvia Domcke

2 papers indexed here

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Open access Oct 2026

A fluctuation test for gastruloid heterogeneity.

Stem cells self-organize into models of early development, but even under carefully controlled conditions, the resulting organoids exhibit substantial "inter-individual" heterogeneity. To explore its origins, we generated monoclonal gastruloids, each derived from a single mouse embryonic stem cell (mESC). Molecular pro...

Samuel G. Regalado, Cheng-Xiang Qiu, Sanjay Kottapalli et al. · 1 citation
Open access Aug 2026

Addressing technical variations in ATAC-seq data and improving motif accessibility analyses

Tagmentation-based methods such as ATAC-seq and Cut&Tag have provided easy ways to profile the epigenome in low-input samples and even single cells. In this contribution, we discuss forms of bias (i.e. technical variations) in tagmentation-based data, in particular ATAC-seq, and introduce three R/bioconductor packages...

Jia-Yi Wang, Emanuel Sonder, Silvia Domcke et al. · 0 citations

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