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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Silvia Fallarini

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Open access Aug 2026

From structure to function: binding determinants of a miniaturised phage depolymerase and their immunological relevance in Klebsiella pneumoniae capsule degradation.

This study provides a comprehensive NMR and mutational analysis to characterise the mechanism of action of a miniaturised depolymerase, here mKP34gp57, targeting the clinically relevant K63 CPS, and shows by NMR that mKP34gp57 hydrolyses CPS with high efficiency through an endoglycosidase-retaining mechanism.

Ferran Nieto-Fabregat, Mario Privitera, Angela Marseglia et al. · 1 citation

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