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Open access Sep 2026

Elevated Plasma DISC1 Levels Are Associated With Motivational Deficits in Medication‐Free Patients With Major Depressive Disorder: An Exploratory Study

ABSTRACT Disrupted‐in‐Schizophrenia 1 (DISC1) has been implicated in major psychiatric disorders, but the relationship between circulating DISC1 protein and dimensional motivation and pleasure‐related features in major depressive disorder (MDD) is unknown. This exploratory cross‐sectional study compared plasma DISC1 le...

Zhen-Hua Zhu, Xu-Yuan Yin, Jia Huang et al. · 0 citations
Open access Sep 2026

The associations of adverse childhood experiences and resilience with psychopathology and addictive behaviour in Chinese patients with substance use disorder.

BACKGROUND Adverse-childhood-experiences (ACEs) are prevalent in substance-use-disorder (SUD) but show complex interplay with resilience, psychopathology and addictive-behaviour. The stress-diathesis model predicts that ACEs can induce psychopathologies and undermine resilience, leading to addictive-behaviour. However,...

Yolanda Y. C. Tsang, Michelle Y. Deng, Raisie W. K. Wong et al. · 0 citations

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